Preheat your oven to 400°F (200°C) and line a baking sheet with parchment paper.
In a large bowl, combine buttermilk, garlic powder, onion powder, smoked paprika, salt, and black pepper. Add the chicken thighs and ensure they are well coated. Cover and refrigerate for at least 30 minutes, or up to 2 hours for more flavor.
In a shallow dish, mix the flour and panko breadcrumbs together. Remove the chicken from the buttermilk marinade, allowing excess to drip off, then dredge each piece in the flour and panko mixture, pressing lightly to adhere.
Place the coated chicken on the prepared baking sheet. Drizzle olive oil over the chicken to help it crisp up while baking.
Bake in the preheated oven for 25-30 minutes, or until the chicken is golden brown and cooked through (internal temperature should reach 165°F).
In the last 5 minutes of baking, drizzle the hot honey over the chicken and return to the oven to caramelize slightly.
Remove from the oven and let rest for a few minutes before serving.